The Investigation Sciences Bureau contains several specialized units that provide support to the investigative bureaus. These specialized units include:

• Crime Scene Command and Control (CSCC) - Detective Sergeants who manage all aspects of a major crime scene including evidence logging and specialist assignments. The scene must be released by CSCC before any portion of the scene may be disturbed by non-ISB personnel. Once released, the scene becomes the purvey of the appropriate investigative bureau. In BSMPD any officer involved shooting is managed as a major crime.
• Crime Scene Forensics (CSF) - crime scene technician specialists - forensic chemistry and trace evidence
• Biological Forensics Unit (BFU) - DNA, Decomposition, and other Biological specialties
• Toxic Substances Unit (TSU) - Specialists in poisons, biological agents, and other toxins
• Weapons and Tools Unit (WTU) - Specialists in ballistics, firearms, and tool marks
• Fingerprint Analysis Unit (FAU) - Latent print specialists
• Imaging Forensics Unit (IFU) - Specialists in photographic, audio and other digital and imaging sciences
• Quality Control Unit (QCU) - verification and process quality controls